All bleeds were successfully managed with alternative factor administration, without adverse events associated with factor administration. Predicated on these promising outcomes, Alnylam plans to progress directly to pivotal research for ALN-AT3 and offers new guidance that it intends to start a pivotal Phase 3 scientific trial in mid-2016. The company also intends to open a Phase 1 open label extension research in late 2015 to supply hemophilia subjects signed up for the Phase 1 research the opportunity for continued dosing; Alnylam intends to statement data from the Stage 1 OLE at least one time per year with initial data anticipated in 2016. Finally, the company still plans on presenting additional data from the ongoing Stage 1 study in late 2015.

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