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4 The Benefits of Sleep in a mouse model of HD.Patrick N. Pallier, Elizabeth S. Maywood, Zhiguang Zheng, Johanna E. Chesham, Alexei N. Inyushkin Richard Dyball, Michael H. Hastings and A. Jennifer Mortonwe usually think of Huntington’s disease with abnormal movements and cognitive impairment, however, these patients show disturbed daily rhythm Sun Pallier et against HD. Model to see R6 / 2 mice with wild-type mice, how might disturbed circadian rhythms influence cognitive performance. Expected, Activity-rest cycles in R6 / 2 mice were irregular. With age, as well as an expression of the circadian proteins mPER1 and mPER2 in the suprachiasmatic nucleus Slices electro – electro – physiological and molecular movement of the SCN appeared intact R6 / 2 mice, which suggests that the intrinsic SCN circuit was operating normally. Hypnotic doses of sedative drug normalized the sleep-wake cycle and improved cognitive performance on the two-choice swim test in the R6 / 2 mice and the expression of the SCN circadian genes regulate While no cure for HD, symptomatic treatment of insomnia seems its advantages.

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